Yes, all normal mouse/keyboard functions still work while Hands Free Poker is running. Hands Free Poker is simply another means to manipulate the poker tables. In fact, it is STRONGLY recommended to use the mouse/keyboard in important situations as ones voice, pitch, etc. can change significantly when one is nervous/excited, etc. The goal of Hands Free Poker is to take the majority of the burden of online poker away from the mouse/keyboard, not to replace it entirely. This tool can be used in conjunction with the mouse/keyboard although it does not need to be.